So what’s the science behind the products?

“Ageing results from the impact of the accumulation of a wide variety of molecular and cellular damage over time.”


World Health Organisation
 

It stands to reason using this knowledge that to reduce ageing, you must repair cell damage. In order to understand the science of repairing cell damage, you must know what sirtuins are and what NAD+ is.

Sirtuins are a family of signalling proteins that assist in metabolism, inflammation, cell cycle, insulin secretion, detoxification and DNA repair. Sirtuins repair cell damage.

Nicotinamide Adenine Dinucleotide, commonly known as NAD+, is a molecule that is found in every living cell and is the fuel for sirtuins. Without NAD+, cells cannot survive. NAD+ fuels sirtuins.

Human NAD+ levels are high at age 20, that’s why you feel so young and healthy and are less prone to disease at that age. Unfortunately, by the time you hit 50, your NAD+ levels are just half of what they were at 20. In order to fight ageing and improve your health you can boost your levels of NAD+, thereby increasing sirtuin activity.

Now for the tricky part - your body can’t absorb NAD+ directly. Supplementing with it has no effect as it just passes straight through you. So you need to use something called a “precursor”. This just means the molecule you supplement with gets turned into the molecule you want by the body's natural processes. One of the precursors for NAD+ is nicotinamide mononucleotide, which is commonly known as NMN.
 

Other compounds have also been found effective in stimulating the activity of the sirtuin proteins. Therefore it follows that if you can both feed and stimulate the sirtuins you can produce even more powerful results.

Resveratrol is a Sirtuin-Activating Compound. There are two types, trans-resveratrol and cis-resveratrol. Trans-resveratrol is more easily absorbed by the body, so that is the one you should use.

Our Morning Supplement provides 1 gram of NMN (the NAD+ precursor) and 1 gram of trans-resveratrol per serving. This is the same dosage that Dr David Sinclair takes. It is important to note that Dr David Sinclair does not endorse any supplement brand.

“Resveratrol is the accelerator pedal, NMN is the fuel.”

Dr David Sinclair, World Leading Anti Ageing Scientist

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